Claringbould Research
Department of Internal Medicine · Erasmus MC, Rotterdam
We are a research group in the Department of Internal Medicine (Pharmacology, Vascular and Metabolic Diseases) at Erasmus MC, Rotterdam, led by Annique Claringbould.
Our research focuses on understanding the changes in gene regulation and gene expression that underlie complex diseases. We combine population genomics, single-cell multiomics, and gene regulatory network approaches to uncover how genetic variants influence disease risk — with a particular focus on type 2 diabetes and familial hypercholesterolaemia.
Join us
We are currently setting up our research group and are excited to invite applications for master internships. If you are a highly motivated and hardworking student, we encourage you to get in touch. Collaboration is at the heart of our work, so we are looking for students with strong communication skills. We especially welcome candidates with a background in bioinformatics, computational biology, genomics, or molecular biology, and an interest in gene regulation, GWAS, lipid biology, or cardiovascular diseases.
News
| Apr 20, 2026 | May at Genome Dynamics course |
|---|---|
| Mar 23, 2026 | Science Days 2026 |
| Mar 12, 2026 | New paper mapping the effect of immune SNPs in CD4+ T cells on bioRxiv |
| Feb 26, 2026 | SUMseq protocol published in Nature Protocols |
| Sep 15, 2025 | Caiwei Tan joined Erasmus MC as the second PhD student in the group! |
Selected Publications
- Genome-scale mapping of variant, enhancer and gene function in primary human CD4+ T cellsbioRxiv, 2026
- Single-cell ultra-high-throughput multiplexed chromatin and RNA profiling reveals gene regulatory dynamicsNature Methods, 2025
- High-Sensitivity C Reactive Protein Mediates Age-Related Vascular Dysfunction: The Rotterdam StudyEuropean Journal of Preventive Cardiology, 2025
- GRaNIE and GRaNPA: inference and evaluation of enhancer-mediated gene regulatory networksMolecular Systems Biology, 2023
- Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expressionNature Genetics, 2021
- Enhancers in disease: molecular basis and emerging treatment strategiesTrends in Molecular Medicine, 2021