Claringbould Research

Department of Internal Medicine · Erasmus MC, Rotterdam

We are a research group in the Department of Internal Medicine (Pharmacology, Vascular and Metabolic Diseases) at Erasmus MC, Rotterdam, led by Annique Claringbould.

Our research focuses on understanding the changes in gene regulation and gene expression that underlie complex diseases. We combine population genomics, single-cell multiomics, and gene regulatory network approaches to uncover how genetic variants influence disease risk — with a particular focus on type 2 diabetes and familial hypercholesterolaemia.

Join us

We are currently setting up our research group and are excited to invite applications for master internships. If you are a highly motivated and hardworking student, we encourage you to get in touch. Collaboration is at the heart of our work, so we are looking for students with strong communication skills. We especially welcome candidates with a background in bioinformatics, computational biology, genomics, or molecular biology, and an interest in gene regulation, GWAS, lipid biology, or cardiovascular diseases.

News

Jun 01, 2026 Phileine and Sam start their summer internships
Apr 20, 2026 May at Genome Dynamics course
Mar 23, 2026 Science Days 2026
Mar 12, 2026 New paper mapping the effect of immune SNPs in CD4+ T cells on bioRxiv
Feb 26, 2026 SUMseq protocol published in Nature Protocols

Selected Publications

  1. Genome-scale mapping of variant, enhancer and gene function in primary human CD4+ T cells
    D.P.I. Moonen*, A. Claringbould*, A.R. Gschwind, S. Schrod, and others
    bioRxiv, 2026
    DOI
  2. Single-cell ultra-high-throughput multiplexed chromatin and RNA profiling reveals gene regulatory dynamics
    S. Lobato-Moreno*, U. Yildiz*, A. Claringbould*, and others
    Nature Methods, 2025
    DOI
  3. High-Sensitivity C Reactive Protein Mediates Age-Related Vascular Dysfunction: The Rotterdam Study
    S. Mohammadi Jouabadi, A. Claringbould, A.H.J. Danser, and others
    European Journal of Preventive Cardiology, 2025
    DOI
  4. GRaNIE and GRaNPA: inference and evaluation of enhancer-mediated gene regulatory networks
    A. Kamal*, C. Arnold*, A. Claringbould, and others
    Molecular Systems Biology, 2023
    DOI
  5. Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression
    U. Võsa*, A. Claringbould*, H.J. Westra, and others
    Nature Genetics, 2021
    DOI
  6. Enhancers in disease: molecular basis and emerging treatment strategies
    A. Claringbould and J.B. Zaugg
    Trends in Molecular Medicine, 2021
    DOI